2-Acetoxybenzoyl chloride → 2,4-Bis(2-acetoxybenzamido)benzoic acid

HRID 1606648Notes

Reaction equation

HRID 1606648 reaction equation
[C:1]([O:4][C:5]1[CH:23]=[CH:22][CH:21]=[CH:20][C:6]=1[C:7]([NH:9][C:10]1[CH:18]=[C:17]([NH2:19])[CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=[O:13])=[O:8])(=[O:3])[CH3:2].[C:24]([O:27][C:28]1[CH:36]=[CH:35][CH:34]=[CH:33][C:29]=1[C:30](Cl)=[O:31])(=[O:26])[CH3:25]>>[C:1]([O:4][C:5]1[CH:23]=[CH:22][CH:21]=[CH:20][C:6]=1[C:7]([NH:9][C:10]1[CH:18]=[C:17]([NH:19][C:30](=[O:31])[C:29]2[CH:33]=[CH:34][CH:35]=[CH:36][C:28]=2[O:27][C:24](=[O:26])[CH3:25])[CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=[O:13])=[O:8])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 796682-Acetoxybenzoyl chlorideHCID 21544120HCID 21544120, compound

Product 1

HCID 1913152,4-Bis(2-acetoxybenzamido)benzoic acid

Procedure

By the procedure similar to that described in Example 23, 2-(2'-acetoxybenzamido)-4-aminobenzoic acid and 2-acetoxybenzoylchloride were allowed to react and were treated to obtain crude crystals. Recrystallization from methanol-water gave 2,4-bis(2'-acetoxybenzamido)-benzoic acid having a melting point between 194° - 195°C. The product wass confirmed to be identical to that obtained in Example 18.

Workup

  1. customto react
  2. additionwere treated
  3. customto obtain crude crystals
  4. customRecrystallization from methanol-water

Sources & evidence

ORD record
ord-678ce2f0ce84406e8407b8d371108ba3
Source dataset
uspto-grants-1976_04
Patent number
US03953496

Reaction notes

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