alpha-Methyl-3-fluorocinnamic acid → 3-(3-Fluorophenyl)-2-methylpropanoic acid

Participants

Reaction Steps

15.6 G. of the above product from Example 4 was hydrogenated at 40 pounds per square inch in 800 ml. of methanol with 3 g. of platinum oxide catalyst. After the theoretical uptake of hydrogen, the hydrogenation was stopped. The catalyst was removed by filtration and the solvent removed in vacuo giving a theoretical yield of the desired product, α-methyl-3-fluorohydrocinnamic acid.

Provenance & Evidence