Sodium Hydroxide → 1-(8-Oxa-3-azabicyclo[3.2.1]oct-3-yl)-1-heptanone

Participants

Reaction Steps

Heptanoyl chloride (14.86 grams, 0.1 mole) was slowly added to a mixture of 8-oxa-3-azabicyclo(3.2.1)octane hydrochloride product of Example 3 (14.96 grams, 0.1 mole) and sodium hydroxide (10 grams) in 300 ml water, at 10° C. After the addition of heptanoyl chloride, the reaction mixture was stirred for 2 hours and then left overnight at room temperature. The product was extracted from the reaction mixture with diethyl ether and treated with DARCO G60 (activated carbon) After the removal of the diethyl ether, the product 3-heptanoyl-8-oxa-3-azabicyclo (3.2.1)octane was obtained as a clear liquid.

Provenance & Evidence