Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Acetoxybenzoyl chloride | HCID 79668 | — |
| Reactant | 8-Oxa-3-azabicyclo[3.2.1]octane | HCID 12069231 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 21544524 | HCID 21544524 | — |
Reaction Steps
o-Acetoxybenzoyl chloride (0.1 mole, 19.85 grams) was slowly added to a mixture of 8-oxa-3-azabicyclo(3.2.1)octane (0.1 mole, 11.13 grams) and triethylamine (0.1 mole) in 60 ml of benzene at 20° C. The reaction mixture was stirred 2.5 hours at 25° C. The salt was filtered off and washed with benzene. After removal of benzene, the product was obtained as a viscous liquid which was purified by column chromatography (alumina). Impurities were eluted with ether and the product with methanol to yield the product represented by formula (IX).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US03953596 |
|---|
| Source dataset | uspto-grants-1976_04 |
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| ORD ID | ord-ea3165aec90f479499dd948299ec83d1 |
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| Source note | uspto-grants-1976_04 |
|---|
