Sodium Hydroxide → 1-Aminotetralin, (S)-

Participants

Reaction Steps

A slurry of 130.3 grams (0.36 mole) of (S)-1,2,3,4-tetrahydro-1-naphthylamine N-benzoyl-(R)-glutamic acid salt in ice and water is made basic by the addition of a cold solution of 34.0 grams (0.847 mole) of sodium hydroxide in water. The liberated amine is extracted with ether. The ether solution is dried over a mixture of magnesium sulfate and sodium hydroxide pellets. The ether is evaporated, and the amine distilled to give the product boiling point 72°C. to 77°C. at 0.6 mm, [α]D25 + 54.9° (c 5.2, benzene).

Provenance & Evidence