Benzene → HCID 21544825, compound

Participants

Reaction Steps

A mixture of 1-(2-carboxychromon-5-yloxy)-2-hydroxy-3-phenoxypropane (10.0 g), ethanol (5 ml), benzene (100 ml) and concentrated sulphuric acid (5 drops) was heated under reflux for 6 hours, the water that formed being collected in a phase separator. The cooled solution was washed with saturated sodium bicarbonate solution and water. Removal of the benzene under reduced pressure yielded 1-(2-carbethoxychromon-5-yloxy)-2-hydroxy-2-phenoxypropane as a viscous oil.

Provenance & Evidence