Sodium Hydroxide → HCID 21544769, compound

Participants

Reaction Steps

A solution of sodium hydroxide (0.6 g) in ethanol was added to 1-(2-carbethoxychromon-5-yloxy)-2-hydroxy-3-p-chlorophenoxypropane (6.28 g) and the mixture was heated under reflux for 1 hour. The resulting sodium salt was filtered, dissolved in the minimum volume of hot water and poured into a solution of acetic acid (100 ml, 2N). The solution was cooled, the precipitated acid was filtered, washed with cold water and dried. Recrystallization from dilute acetic acid gave 1-(2-carboxychromon-5-yloxy)-2-hydroxy-3-p-chlorophenoxypropane (6.0 g) as white needles, m.p. 193°-195° C.

Provenance & Evidence