o-CRESYL GLYCIDYL ETHER → HCID 21544835, compound

Participants

Reaction Steps

A solution of 2,6-dihydroxyacetophenone (15.2 g) and o-cresylglycidyl ether (16.4 g) in 2-ethoxyethanol (75 ml) containing benzyltrimethylammonium hydroxide solution (10 drops; 40%) was heated under reflux for 48 hours. Following removal of the 2-ethoxyethanol under reduced pressure, the resulting solid was washed with ether to give 1-(2-acetyl-3-hydroxyphenoxy)-2-hydroxy-3-o-cresyloxypropane (19.2 g) as a cream solid, m.p. 101°-102.5° C.

Provenance & Evidence