HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyltrimethylammonium hydroxide → 1-(2-Acetyl-3-hydroxyphenoxy)-2-hydroxy-3-m-cresyloxypropane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyltrimethylammonium hydroxide | HCID 66854 | — |
| Reactant | 2',6'-Dihydroxyacetophenone | HCID 69687 | — |
| Reactant | ((m-Tolyloxy)methyl)oxirane | HCID 98180 | — |
| Solvent | Glycol monoethyl ether | HCID 8076 | — |
| Product | 1-(2-Acetyl-3-hydroxyphenoxy)-2-hydroxy-3-m-cresyloxypropane | HCID 21544782 | 99.7% |
Reaction Steps
A solution of 2,6-dihydroxyacetophenone (15.2 g), m-cresylglycidyl ether (16.4 g) and benzyltrimethylammonium hydroxide (10 drops of a 40% solution) in 2-ethoxyethanol (75 ml) was heated under reflux for 48 hours. The solvent was then removed under reduced pressure to give 1-(2-acetyl-3-hydroxyphenoxy)-2-hydroxy-3-m-cresyloxypropane (31.5 g) as a viscous amber oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03953604 |
| Source dataset | uspto-grants-1976_04 |
| ORD ID | ord-2b1b1c294c094e47b786ad98c73911e8 |
| Source note | uspto-grants-1976_04 |