化工社化工社 化学情報印刷レポート · 研究参考用
Iodine → L-Leucine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodine | HCID 807 | — |
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | N-[(Phenylmethoxy)carbonyl]-L-leucine 2,5-dioxo-1-pyrrolidinyl ester | HCID 11089751 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | L-Leucine | HCID 6106 | — |
反応手順
Z-Leu-OSu (LXIII) (10.8 gm), and the above TFA salt (LXIV) (17.8 gm) in DMF (200 mg) and Et3N (8.4 ml), were stirred at room temperature for 24 hours. The reaction mixture was evaporated in vacuo and the resulting peptide was partitioned between H2O and CHCl3. The dried (Na2SO4) organic layer was evaporated and crystallized from acetone-MeOH to afford 17.7 gm (80%) of pure LXV: m.p. 138°-140°C; [α]D22 -35.4 (c, 1.16, MeOH); Rf1 0.86 and Rf3 0.68, single spot with I2 reagent. Amino acid analysis gave Leu 1.1; Arg 0.9; Pro 1.0; Gly 1.0; NH3 0.9.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03953416 |
| 出典データセット | uspto-grants-1976_04 |
| ORD ID | ord-3a08098f79d9417c85401e9cea21e768 |
| 出典メモ | uspto-grants-1976_04 |