Dicyclohexylcarbodiimide → HCID 131710172, compound

Participants

Reaction Conditions

Reaction Steps

2.59 g. (8 mmoles) of Z-Asn-Gly-OH, 6.65 g. (8 mmoles) of H-Ala-Glu(OtBu)-Asp(OtBu)-Glu(OtBu)-Ser(tBu)-OtBu and 4.86 g. of pentafluorophenol are dissolved in 28 ml. of DMF. The solution is cooled to 0° C, and 1.81 g. (8.8 mmoles) of DCC are added to it. The reaction mixture is stirred at 0° C for 0.5 hours, and stirring is continued at room temperature for 2.5 hours. The separated DCU is removed by filtration; the filtrate is evaporated to dryness, and the residue is triturated with ethyl acetate. 7.3 g. (80.5 %) of Z-25-31-OtBu are obtained. M.p.: 194° C (under decomposition), Rf3 = 0.6.

Provenance & Evidence