HCID 131710180, compound → HCID 131710181, compound

Participants

Reaction Steps

A solution of 4.0 g. (3.48 mmoles) of Z-25-32-OtBu in 140 ml. of methanol is hydrogenated in the presence of 0.5 g. of palladium-on-carbon. When the reaction terminates, the catalyst is filtered off; the filtrate is evaporated to dryness; the residue is triturated with ether and filtered off. 3.4 g. (96 %) of H-25-32-OtBu are obtained. M.p.: 188°-190°C; Rf4 = 0.5; [α]D = -6.6° (c = 0.89, in DMF).

Provenance & Evidence