Potassio isocyanate → HCID 67929746, compound

HRID 1606849Notes

Reaction equation

HRID 1606849 reaction equation
Cl.[OH:2][C:3]1[CH:12]=[C:11]([NH2:13])[CH:10]=[CH:9][C:4]=1[O:5][CH:6]([OH:8])[CH3:7].[N-:14]=[C:15]=[O:16].[K+]>O>[OH:2][C:3]1[CH:12]=[C:11]([NH:13][C:15]([NH2:14])=[O:16])[CH:10]=[CH:9][C:4]=1[O:5][CH:6]([OH:8])[CH3:7]

Participants

4

Reactant 2

HCID 11051572Potassio isocyanateHCID 67929739HCID 67929739, compound

Product 1

HCID 67929746HCID 67929746, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

0.03 mol (6.16 g) of 2-hydroxy-4-aminophenoxyethanol hydrochloride is dissolved in 34 ml of water at 15° C. 0.03 mol (2.43 g) of potassium isocyanate dissolved in 7.5 ml of water is added to this solution, with stirring. The temperature of the reaction medium rises to 25° C. After stirring for 30 minutes, the expected product which has precipitated is filtered off. It is washed with a normal solution of hydrochloric acid and then with water. After recrystallization from acetic acid and drying in vacuo, the product melts at 191° C.

Workup

  1. additionis added to this solution
  2. customrises to 25° C
  3. stirringAfter stirring for 30 minutes
  4. customthe expected product which has precipitated
  5. filtrationis filtered off
  6. washIt is washed with a normal solution of hydrochloric acid
  7. customAfter recrystallization from acetic acid
  8. customdrying in vacuo

Sources & evidence

ORD record
ord-ca3dec9211924f4282ddbb98e6154f33
Source dataset
uspto-grants-1989_09
Patent number
US04863480

Reaction notes

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