Sodium Methoxide → 2-(Betahydroxyethyl)amino-6-(beta-hydroxyethyl)amino-4-methoxynitrobenzene
Reaction equation
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[C:9](Cl)[CH:8]=[C:7]([NH:12][CH2:13][CH2:14][OH:15])[C:6]=1[N+:16]([O-:18])=[O:17].[CH3:19][O-:20].[Na+]>CO>[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[C:9]([O:20][CH3:19])[CH:8]=[C:7]([NH:12][CH2:13][CH2:14][OH:15])[C:6]=1[N+:16]([O-:18])=[O:17]Participants
4
Procedure
0.09 mole (25 g) of 2-(β-hydroxyethyl)amino-6-(β-hydroxyethyl)amino-4-chloronitrobenzene in 100 ml of a 25% sodium methylate solution in methanol was heated over a boiling water bath. After heating for 1 hour 30 minutes the desired product was precipitated out of the reaction medium by adding 250 g of ice water. After filtering and hot drying under vacuum in the presence of P2O5, the desired product was recrystallized from 96° ethanol. It melted at 150° C.
Sources & evidence
- ORD record
- ord-56011de210fd421f9aaef79035e30a3a
- Source dataset
- uspto-grants-1989_09
- Patent number
- US04863482
Reaction notes
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