反应详情

In 20 ml of ethanol was dissolved 2.62 g (10 mmols) of 5-(1,3-dimethyl-1H-pyrazol-4-yl)-2-propionylcyclohexane-1,3-dione and, 30 ml (12 mmols) of 0.4 mol ethanolic solution of (E)-3-chloro-2-propenyloxyamine was added to the solution. The mixture was reacted for 8 hours with stirring. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (chloroform:methanol=50:1) to give 3.21 g of the product.

1. additionwas added to the solution
2. customThe mixture was reacted for 8 hours
3. customAfter completion of the reaction
4. concentrationthe reaction mixture was concentrated under reduced pressure
5. customThe resulting crude product was purified by silica gel column chromatography (chloroform:methanol=50:1)