Methyl 1-acetylamino-2-chloro-5a,6,7,8,9,9a-hexahydrodibenzofuran-4-carboxylate → 1-Amino-2-chloro-6,7,8,9-tetrahydrodibenzofuran-4-carboxylic acid 1-amino-2-chlorodibenzofuran-4-carboxylic acid

HRID 1606910Notes

Reaction equation

HRID 1606910 reaction equation
C([NH:4][C:5]1[C:13]2[CH:12]3[CH2:14][CH2:15][CH2:16][CH2:17][CH:11]3[O:10][C:9]=2[C:8]([C:18]([O:20]C)=[O:19])=[CH:7][C:6]=1[Cl:22])(=O)C.C([NH:26][C:27]1[C:35]2[C:34]3[CH2:36][CH2:37][CH2:38][CH2:39][C:33]=3[O:32][C:31]=2[C:30]([C:40]([O:42]C)=[O:41])=[CH:29][C:28]=1[Cl:44])(=O)C.C(NC1C2C3C=CC=CC=3OC=2C(C(OC)=O)=CC=1Cl)(=O)C>>[NH2:4][C:5]1[C:13]2[C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[O:10][C:9]=2[C:8]([C:18]([OH:20])=[O:19])=[CH:7][C:6]=1[Cl:22].[NH2:26][C:27]1[C:35]2[C:34]3[CH2:36][CH2:37][CH2:38][CH2:39][C:33]=3[O:32][C:31]=2[C:30]([C:40]([OH:42])=[O:41])=[CH:29][C:28]=1[Cl:44]

Participants

4

Reactant 3

HCID 15136047Methyl 1-acetylamino-2-chloro-5a,6,7,8,9,9a-hexahydrodibenzofuran-4-carboxylateHCID 15136065Methyl 1-acetylamino-2-chloro-6,7,8,9-tetrahydrodibenzofuran-4-carboxylateHCID 15136066Methyl 1-acetylamino-2-chlorodibenzofuran-4-carboxylate

Product 1

HCID 700540011-Amino-2-chloro-6,7,8,9-tetrahydrodibenzofuran-4-carboxylic acid 1-amino-2-chlorodibenzofuran-4-carboxylic acid

Procedure

When the procedure of Example 15 is followed however methyl 1-acetylamino-2-chloro-5a,6,7,8,9,9a-hexahydrodibenzofuran-4-carboxylate is replaced by methyl 1-acetylamino-2-chloro-6,7,8,9-tetrahydro-dibenzofuran-4-carboxylate or methyl 1-acetylamino-2-chlorodibenzofuran-4-carboxylate then the captioned products are prepared.

Workup

  1. customthe captioned products are prepared

Sources & evidence

ORD record
ord-8b213370aef341cd831978c58575539f
Source dataset
uspto-grants-1989_09
Patent number
US04863921

Reaction notes

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