Water → HCID 70394522, compound

Participants

Reaction Steps

109.03 g (300 mmol) of (S)-8-bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid was decarboxylated at 290°. The melt was dissolved in about 400 ml of N,N-dimethylformamide and the solution was poured into 2.5 l of water. After stirring for 30 minutes the precipitated product was filtered off, rinsed with water and dried. There was obtained (S)-8-bromo-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-one of melting point 232°-233°.

Provenance & Evidence