Iodine → HCID 53912151, compound

Participants

Reaction Steps

15.90 g (50 mmol) of (S)-8-bromo-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one was stirred at 100° for 3 hours with 44 g (175 mmol) of iodine and 14 g (100 mmol) of potassium carbonate in 100 ml of N,N-dimethylformamide. The reaction mixture was poured into 1 l of water and, after stirring for 30 minutes, the precipitated product was filtered off. The filter residue was rinsed with water, dried and recrystallized from N,N-dimethylformamide. There was obtained (S)-8-bromo-11,12,13,13a-tetrahydro-1-iodo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one of melting point 301°-303°.

Provenance & Evidence