Carbon Dioxide → HCID 19851550, compound

HRID 1607017Notes

Reaction equation

HRID 1607017 reaction equation
[Cl:1][C:2]1[C:7]2[C:8](=[O:19])[NH:9][CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3C(O)=O)[C:6]=2[CH:5]=[CH:4][C:3]=1[F:20].[C:21](=O)=O>C(O)C>[Cl:1][C:2]1[C:7]2[C:8](=[O:19])[N:9]([CH3:21])[CH2:10][C:11]3[N:12]([CH:13]=[N:14][CH:15]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[F:20]

Participants

4

Reactant 2

HCID 280Carbon DioxideHCID 19851585HCID 19851585, compound

Product 1

HCID 19851550HCID 19851550, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

11.64 g (37.5 mmol) of 7-chloro-8-fluoro-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid was heated to 285° in a metal bath until the CO2 cleavage has finished. The melt was poured into 50 ml of ethanol and the precipitated product was filtered off under suction and washed with ethanol. After drying there was obtained 7-chloro-8-fluoro-4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one of melting point 234°-235°.

Workup

  1. filtrationthe precipitated product was filtered off under suction
  2. washwashed with ethanol
  3. customAfter drying there

Sources & evidence

ORD record
ord-1b6ecfcc8cf74e6bbf5f0f55c0c11129
Source dataset
uspto-grants-1989_09
Patent number
US04863920

Reaction notes

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