Sodium Hydroxide → HCID 19735070, compound

HRID 1607019Notes

Reaction equation

HRID 1607019 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]2[C:15]3[CH:16]=[CH:17][CH:18]=[C:19]([CH3:20])[C:14]=3[C:13](=[O:21])[N:12]([CH3:22])[CH2:11][C:10]=12)=[O:5])C.[OH-].[Na+]>C(O)C.O>[CH3:22][N:12]1[C:13](=[O:21])[C:14]2[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][C:15]=2[N:9]2[CH:8]=[N:7][C:6]([C:4]([OH:5])=[O:3])=[C:10]2[CH2:11]1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 19735052HCID 19735052, compound

Product 1

HCID 19735070HCID 19735070, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

25 g (85 mmol) of ethyl-5,6-dihydro-5,7-dimethyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate was heated to boiling under reflux for 1 hour with 3.40 g (85 mmol) of sodium hydroxide in 200 ml of ethanol and 15 ml of water. After evaporation of the ethanol the residue was diluted with water and acidified with 21 ml of 4N hydrochloric acid. The suspension obtained was suction filtered and washed with water. By drying the filter cake there was obtained 5,6-dihydro-5,7-dimethyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid of decomposition point 274°-275°.

Workup

  1. customAfter evaporation of the ethanol the residue
  2. additionwas diluted with water
  3. customThe suspension obtained
  4. filtrationfiltered
  5. washwashed with water
  6. customBy drying the filter cake

Sources & evidence

ORD record
ord-3860222e3c20471a800f306b0fee8e75
Source dataset
uspto-grants-1989_09
Patent number
US04863920

Reaction notes

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