Ethanol → tert-Butyl 4-(3-hydroxyphenyl)piperazine-1-carboxylate

HRID 160704Notes

Reaction equation

HRID 160704 reaction equation
[CH3:44][CH2:45][OH:46].[O:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]1[O:7][c:8]1[cH:9][c:10]([N:14]2[CH2:15][CH2:16][N:17]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:18][CH2:19]2)[cH:11][cH:12][cH:13]1.[c:27]1([CH3:28])[cH:29][cH:30][c:31]([S:32]([O-:33])(=[O:34])=[O:35])[cH:36][cH:37]1.[nH+:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1>>[OH:7][c:8]1[cH:9][c:10]([N:14]2[CH2:15][CH2:16][N:17]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:18][CH2:19]2)[cH:11][cH:12][cH:13]1

Participants

5

Reactant 4

HCID 702EthanolHCID 85570p-ToluenesulfonateHCID 4989215PyridiniumHCID 23081281Tert-butyl 4-[3-(tetrahydropyran-2-yloxy)phenyl]piperazine-1-carboxylate

Product 1

HCID 18669061tert-Butyl 4-(3-hydroxyphenyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-9e97e6b2b58344eba6687c43f33d733c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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