Ammonia → 3-[4-(5-Bromo-3-methylpyrid-2-yl)-butylamino]-4-amino-1,2,5-thiadiazole-1-oxide

Participants

Reaction Conditions

Reaction Steps

A solution of 3,4-dimethoxy-1,2,5-thiadiazole-1-oxide (1.62 g) in methanol has reacted with a solution of 4-(5-bromo-3-methylpyrid-2-y)-butylamine (2.43 g) in methanol. After 2 hours at room temperature, the reaction was cooled to 0° C. and saturated by passing ammonia gas for 10 mins. After 1.5 hours the product (which precipitated) was filtered off and recrystallised from ethanol to yield 3-[4-(5-bromo-3-methylpyrid-2yl)-butylamino]-4-amino-1,2,5-thiadiazole-1-oxide (1.2 g) m.p. 188°-190° C.

Provenance & Evidence