Methyl chloroformate → HCID 14191602, compound

HRID 1607068Notes

Reaction equation

Cl[C:2]([O:4]C)=[O:3].Br[C:7]1[CH:8]=[C:9]2[C:22]3[C:12]([CH2:13][C@@H:14]4[C@@H:19]([C:20]=3[CH:21]=1)[CH2:18][C@H:17]([NH:23][C:24](=[O:30])[N:25]([CH2:28][CH3:29])[CH2:26][CH3:27])[CH2:16][N:15]4[CH3:31])=[CH:11][N:10]2[Si](C(C)(C)C)(C)C>>[CH2:28]([N:25]([CH2:26][CH3:27])[C:24](=[O:30])[NH:23][C@H:17]1[CH2:18][C@H:19]2[C@@H:14]([CH2:13][C:12]3[C:22]4[C:9](=[CH:8][C:7]([C:2]([OH:4])=[O:3])=[CH:21][C:20]2=4)[NH:10][CH:11]=3)[N:15]([CH3:31])[CH2:16]1)[CH3:29]

Participants

Reactant 2

HCID 6586Methyl chloroformate

HCID 13823172HCID 13823172, compound

Product 1

HCID 14191602HCID 14191602, compound

Procedure

With methyl chloroformate and 3-(13-bromo-1-tert-butyldimethylsilyl-6-methyl-8α-ergolinyl)-1,1-diethylurea:

Sources & evidence

ORD record: ord-55d09b83c3274e97911ab1d6121ce117
Source dataset: uspto-grants-1989_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04863929

Reaction notes

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