Acetic Anhydride → HCID 86743346, compound

HRID 1607079Notes

Reaction equation

HRID 1607079 reaction equation
[CH2:1]([N:3]([CH2:25][CH3:26])[C:4]([NH:6][C@H:7]1[CH2:21][C@H:20]2[C@@H:10]([CH2:11][C:12]3[C:22]4[C:15](=[CH:16][C:17]([OH:23])=[CH:18][C:19]2=4)[NH:14][CH:13]=3)[N:9]([CH3:24])[CH2:8]1)=[O:5])[CH3:2].[C:27](OC(=O)C)(=[O:29])[CH3:28]>N1C=CC=CC=1>[C:27]([O:23][C:17]1[CH:16]=[C:15]2[C:22]3[C:12]([CH2:11][C@@H:10]4[C@@H:20]([C:19]=3[CH:18]=1)[CH2:21][C@H:7]([NH:6][C:4](=[O:5])[N:3]([CH2:1][CH3:2])[CH2:25][CH3:26])[CH2:8][N:9]4[CH3:24])=[CH:13][NH:14]2)(=[O:29])[CH3:28]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 13823178HCID 13823178, compound

Product 1

HCID 86743346HCID 86743346, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

At room temperature, 100 mg of 1,1-diethyl-3-(13-hydroxy-6-methyl-8α-ergolinyl)urea is dissolved in 1 ml of pyridine and 1 ml of acetic anhydride. After one hour, the mixture is poured on ice, extracted, after 15 minutes of stirring, with methylene-chloride, the organic phase is dried with sodium sulfate, and evaporated. The residue is crystallized from ethyl acetate.

Workup

  1. additionthe mixture is poured on ice
  2. extractionextracted, after 15 minutes
  3. dry with materialthe organic phase is dried with sodium sulfate
  4. customevaporated
  5. customThe residue is crystallized from ethyl acetate

Sources & evidence

ORD record
ord-792727fc59564968aac83882816b5822
Source dataset
uspto-grants-1989_09
Patent number
US04863929

Reaction notes

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