反应详情

4.4 g (40 mmol) of 6-amino-2-hydroxypyridine are heated under reflux for 12 hurs in 30 ml of orthoacetic acid trimethyl ester The reaction mixture is then concentrated by evaporation Ether is added to the residue while stirring, the product crystallising out spontaneously. The product is filtered off with suction and dried under a high vacuum. N-(2-hydroxy-6-pyridyl)-acetimidic acid methyl ester having a melting point of 128°-129° is thus obtained.

1. concentrationis then concentrated by evaporation Ether
2. additionis added to the residue
3. customthe product crystallising out spontaneously
4. filtrationThe product is filtered off with suction
5. customdried under a high vacuum