Trimethyl orthoacetate → HCID 178495861, compound

HRID 1607085Notes

Reaction equation

HRID 1607085 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][CH:3]=1.[CH3:9][O:10][C:11](OC)(OC)[CH3:12]>>[CH3:9][O:10][C:11](=[N:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][CH:3]=1)[CH3:12]

Participants

3

Reactant 2

HCID 15050Trimethyl orthoacetateHCID 1785076342-Amino-6-hydroxypyridine

Product 1

HCID 178495861HCID 178495861, compound

Procedure

4.4 g (40 mmol) of 6-amino-2-hydroxypyridine are heated under reflux for 12 hurs in 30 ml of orthoacetic acid trimethyl ester The reaction mixture is then concentrated by evaporation Ether is added to the residue while stirring, the product crystallising out spontaneously. The product is filtered off with suction and dried under a high vacuum. N-(2-hydroxy-6-pyridyl)-acetimidic acid methyl ester having a melting point of 128°-129° is thus obtained.

Workup

  1. concentrationis then concentrated by evaporation Ether
  2. additionis added to the residue
  3. customthe product crystallising out spontaneously
  4. filtrationThe product is filtered off with suction
  5. customdried under a high vacuum

Sources & evidence

ORD record
ord-3be86dfd3d214280b3f286795a2c6ffe
Source dataset
uspto-grants-1989_09
Patent number
US04863938

Reaction notes

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