Isobutylamine → HCID 19851815, compound

Participants

Reaction Steps

N-triphenylmethyl-2-paranitrophenoxycarbonylthioethylamine (300 mg) and isobutylamine (185 μl) were subjected to similar reactions to those described in References 2 and 4 to give 2-isobutylaminocarbonylthioethylamine (crude formate: 256 mg) which was then dissolved in anhydrous methanol (5 ml). Triethylamine (376 μl) and mitomycin A (151 mg: 0.8 molar equivalent) were added to the solution. The reaction solution was treated in a similar manner to that described in Example 1 to obtain Compound 24 (71 mg) in the form of grayish blue powders with a yield of 33%.

Provenance & Evidence