2-Pyridineethanamine → HCID 54077914, compound
Reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[NH:8][CH2:9][CH2:10][S:11][C:12](OC2C=CC([N+]([O-])=O)=CC=2)=[O:13])C=CC=CC=1.[NH2:36][CH2:37][CH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][N:40]=1>>[N:40]1[CH:41]=[CH:42][CH:43]=[CH:44][C:39]=1[CH2:38][CH2:37][NH:36][C:12]([S:11][CH2:10][CH2:9][NH2:8])=[O:13]Participants
3
Procedure
N-triphenylmethyl-2-paranitrophenoxycarbonylthioethylamine (500 mg) and 2-(2-aminoethyl)pyridine (375 μl) were subjected to the reactions described in References 2 and 4 to give 2-(2-pyridyl)ethylaminocarbonylthioethylamine (crude formate: 218 mg). The product (190 mg) was dissolved in anhydrous methanol (3 ml), to which were then added triethylamine (490 μl) and mitomycin A (245 mg: 1.0 molar equivalent). The reaction solution was treated in a similar manner to that described in Example 1 to obtain Compound 49 (297 mg) in the form of grayish blue powders with a yield of 78%.
Sources & evidence
- ORD record
- ord-92b34155b75e4ac9bc51edc98641a384
- Source dataset
- uspto-grants-1989_09
- Patent number
- US04863935
Reaction notes
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