Formic Acid → 2-Methylaminocarbonylthioethylamine (formate)

Participants

Reaction Conditions

Reaction Steps

To N-triphenylmethyl-2-methylaminocarbonylthioethylamine (306 mg) which was prepared by the method of Reference 2 was added formic acid (98%; 5 ml). The reaction solution was stirred at a temperature of 50° C. for 30 minutes and was then concentrated under reduced pressure. The resultant residue was purified without after-treatment by silica gel chromatography using a solvent system of chloroform/methanol/water (6:5:1 v/v) to obtain 139 mg of the desired product with a yield of 95%.

Provenance & Evidence