Pyrrolidone carboxylic acid → HCID 11287601, compound

Participants

Reaction Steps

A 200-ml eggplant-shaped flask equipped with a condenser and a mechanical stirrer was charged with 6.5 g (0.05 mole) of 2-pyrrolidone-5-carboxylic acid, 23.2 g (0.20 mole) of n-heptyl alcohol, a catalytic amount of concentrated sulfuric acid and 40 ml of benzene and the mixture was refluxed for 3.5 hours. The reaction mixture was cooled to room temperature and poured into saturated aqueous NaHCO3, followed by extraction with benzene. Washing, drying, solvent removal and distillation under reduced pressure as performed in the conventional manner gave 7.4 g of yellow 2-pyrrolidone-5-carboxylic acid n-heptyl ester. Boiling point: 186°-188° C./3 mm Hg.

Provenance & Evidence