Trifluoroacetic acid → HCID 14463815, compound

Participants

Reaction Steps

(3R)-3-t-Butoxycarbonylamino-1-benzyloxypyrrolidin-2-one (Example 1(c), 19.02 g, 62.2 mmol) was dissolved in trifluoracetic acid (150 ml). After 15 mins the solution was evaporated and the residue was crystallised from diethyl ether to give the title compound (20.31 g, 100%). mp=185° C. [α]D =+41.4° (c=1% MeOH), 1H NMR δ (D2O) 7.52-7.48 (5H, m, phenyl), 5.04 (2H, s, OCH2), 4.13 (1H, t, J=9.26 Hz, αCH--CH2), 3.63-3.59 (2H, m, CH2 --N), 2.61-2.57 (1H, m, --CH--CHA --HB), 2.13-2.02 (1H, m, --CH--CHAHB). m/e (FAB+) 207 (M+1); (FAB-) 205 (M-1).

Provenance & Evidence