Sodium Hydroxide → HCID 19851964, compound

HRID 1607148Notes

Reaction equation

HRID 1607148 reaction equation
C[O:2][C:3](=[O:33])[C:4]([NH:6][C:7]1[C:12]([CH3:13])=[CH:11][C:10]([Br:14])=[C:9]([O:15][CH2:16][CH2:17][CH2:18][O:19][C:20]2[CH:25]=[CH:24][C:23]([C:26](=[O:28])[CH3:27])=[C:22]([OH:29])[C:21]=2[CH2:30][CH2:31][CH3:32])[CH:8]=1)=[O:5].[OH-].[Na+]>CO>[C:26]([C:23]1[CH:24]=[CH:25][C:20]([O:19][CH2:18][CH2:17][CH2:16][O:15][C:9]2[CH:8]=[C:7]([NH:6][C:4](=[O:5])[C:3]([OH:33])=[O:2])[C:12]([CH3:13])=[CH:11][C:10]=2[Br:14])=[C:21]([CH2:30][CH2:31][CH3:32])[C:22]=1[OH:29])(=[O:28])[CH3:27]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54275004HCID 54275004, compound

Product 1

HCID 19851964HCID 19851964, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 15.1 g (29 mmol) of N-{3-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy)-propoxy]-4-bromo-6-methylphenyl}-oxamic acid methyl ester in 120 ml of methanol and 30.4 ml of N sodium hydroxide solution is heated under reflux for 90 minutes. The reaction mixture is concentrated under reduced pressure, dissolved in acetone and dilute sodium hydroxide solution and acidified with dilute hydrochloric acid. The product that has formed is filtered off, washed with acetone/water and recrystallised from isopropanol. N-{3-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy)-propoxy]-4-bromo-6-methylphenyl}-oxamic acid having a melting point of 191°-192° is obtained. 10.9 g (21.5 mmol) of this product are dissolved in 450 ml of isopropanol under reflux, and a solution of 3.20 g (21.5 mmol) of triethanolamine in 30 ml of isopropanol is then added thereto. The solution is cooled and concentrated to approximately one third under reduced pressure. After the addition of ether, crystallisation begins. The product that has formed is filtered off and washed with ether. The triethanolammonium salt of N-{3-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy)-propoxy]-4-bromo-6-methylphenyl}-oxamic acid having a melting point of 85°-86° is obtained.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 90 minutes
  3. concentrationThe reaction mixture is concentrated under reduced pressure
  4. dissolutiondissolved in acetone
  5. customThe product that has formed
  6. filtrationis filtered off
  7. washwashed with acetone/water
  8. customrecrystallised from isopropanol

Sources & evidence

ORD record
ord-21e2b778522e4ada94e032e970d1c4d3
Source dataset
uspto-grants-1989_09
Patent number
US04863942

Reaction notes

Loading…