反应详情

2.5 g of 10% palladium-on-carbon are added to a solution of 10 g (25.1 mmol) of 2-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propoxy]-6-nitrobenzonitrile and 10 g of cyclohexene in 500 ml of ethanol and the whole is heated under reflux for 30 minutes. After cooling to room temperature the mixture is filtered and freed of solvent. Ether is added to the residue and the crystals that have separated out are filtered off. 2-amino-6-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy)-propoxy]-benzonitrile having a melting point of 120°-122° C. is obtained.

1. temperaturethe whole is heated
2. temperatureunder reflux for 30 minutes
3. filtrationis filtered
4. additionEther is added to the residue
5. customthe crystals that have separated out
6. filtrationare filtered off