Sodium Chloride → HCID 178428182, compound

Participants

Reaction Steps

To a suspension of 3.5 g. lithium aluminium hydride in 100 ml. tetrahydrofuran is added dropwise at ambient temperature a solution of 5.3 g. (19 mmole) 7,7-dimethyl-6,7-dihydro-2-(pyridin-4-yl)-3H,5H-pyrrolo[2,3-f]benzimidazol-6-one. The reaction mixture is heated to reflux for 6 hours, decomposed with an aqueous solution of sodium chloride, extracted with dichloromethane and methanol, dried, evaporated and chromatographed on silica gel, 1.9 g. (38% of theory) of the title compound being eluted; m.p. 147°-149° C.

Provenance & Evidence