Methanol → HCID 178429214, compound

Participants

Reaction Steps

3.1 g. 5,6-Diamino-3,3-dimethylindolin-2-one and 2.5 g. indole-3-aldehyde are stirred for 4 days at ambient temperature in 150 ml. methanol and 4 ml. glacial acetic acid. The solvent is then removed in a vacuum and the residue is purified by column chromatography on silica gel. The appropriate fractions are combined, the solvent is removed in a vacuum, the residue (3.7 g. of a yellow oil) is dissolved in methanol, dichloromethane added thereto until turbidity commences and then left to crystallise. There are obtained 3.1 g. of the title compound; m.p. 243°-245° C.

Provenance & Evidence