Benzaldehyde → HCID 178473795, compound

Participants

Reaction Steps

A mixture of 2.2 g. (10 mmole) 1-acetyl-5,6-diamino-3,3-dimethylindoline, 200 ml. methanol, 5.2 ml. acetic acid, 1.0 ml. benzaldehyde and 50 mg. manganese dioxide is stirred for 3 hours at ambient temperature while passing in air. The reaction mixture is then filtered, the filtrate evaporated and the residue chromatographed on silica gel. After evaporation of the appropriate fractions and trituration with diethyl ether, there is obtained 0.8 g. (26% of theory) of the title compound; m.p. 225°-227° C.

Provenance & Evidence