反应详情

A mixture of 9.59 g of 4-amino-2,3-difluorobenzonitrile and 20 mL of Ac2O is heated for 1 hour on a steam bath. The red solution is cooled in an ice bath and the resulting faint pink crystals filtered off, washed with 2×10 mL of Et2O and air dried. In this manner there is obtained 8.26 g (67% yield) of 4'-cyano-2',3'-difluoroacetanilide, m.p. 175°-177° C. with the appropriate NMR and IR spectral data and an ion at 197 in the mass spectrum.

1. temperatureis heated for 1 hour on a steam bath
2. temperatureThe red solution is cooled in an ice bath
3. filtrationthe resulting faint pink crystals filtered off
4. washwashed with 2×10 mL of Et2O and air
5. customdried