Iodine → HCID 14621050, compound

Participants

Reaction Steps

In 4.8 mL of HOAc, 0.5 g of 4-acetyl-2-chloro-5-fluoroaniline and 0.47 g of HgO are stirred under N2. At room temperature over 4 hours, 0.79 g of I2 is added and after stirring an additional hour, the mixture is filtered and the filter cake washed with 3 mL of AcOH To the filtrate and washed solution, 75 mL of H2O is added to precipitate the title compound, which is collected, washed with H2O and air dried to afford 0.83 g, m.p. 117°-119° C.

Provenance & Evidence