Sodium Hydroxide → HCID 14621097, compound

Participants

Reaction Steps

A stirred mixture consisting of 3.6 g of 4-acetamido-α-[(tert-butylamino)methyl]-2,5-difluorobenzyl alcohol, 36 mL of EtOH and 36 mL of 10% aqueous NaOH is heated at reflux under N2 for 4 h. The EtOH is evaporated in vacuo and the residue is extracted with 4×60 mL of CH2Cl2. The combined organic extracts are washed with 25 mL of H2O, dried with anhydrous Na2SO4 and evaporated in vacuo to furnish the title compound which is crystallized from CH3CN/hexane, 2.77 g (90% yield), m.p. 115°-116° C.

Provenance & Evidence