Acetic Acid → HCID 67944782, compound

Participants

Reaction Steps

In a 1000 ml round bottomed flask equipped with a reflux condensor was placed 100 g 4-chlorophenyl benzyl ketone (0.43 mole), 400 ml of methanol, 40 ml of 37% formalin (0.67 mole), 5 g of piperidine, and 5 g of acetic acid. The resulting mixture was refluxed for 2 hours, concentrated in vacuo, partitioned between ethyl ether and water, washed with water, dried over anhydrouis magnesium sulfate and concentrated in vacuo to yield 98 g of 2-phenyl 4'-chlorophenyl acrylophenone, an oil. NMR data was consistent with the structure.

Provenance & Evidence