HCID 19852123, compound → 3-(4-chlorophenyl)-4-carbomethoxy-4-methyl-4,5-dihydro-1H-pyrazole hydrochloride

HRID 1607216Notes

Reaction equation

HRID 1607216 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:14]([O:16][CH3:17])=[O:15])([CH3:13])[CH2:11][NH:10][N:9]=2)=[CH:4][CH:3]=1>CCOCC>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]([C:14]([O:16][CH3:17])=[O:15])([CH3:13])[CH2:11][NH:10][N:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 19852123HCID 19852123, compound

Product 1

HCID 198521223-(4-chlorophenyl)-4-carbomethoxy-4-methyl-4,5-dihydro-1H-pyrazole hydrochlorideYield 194.9%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To an ether solution containing approximately 14 g (55 mmole) of 3-(4-chlorophenyl)-4-carbomethoxy-4-methyl-4,5-dihydro-1H-pyrazole (Example O) was bubbled excess anhydrous hydrogen chloride. The precipitated solid was filtered, washed with ether and dried yielding 15.5 g (53.6 mmole) of 3-(4-chlorophenyl)-4-carbomethoxy-4-methyl-4,5-dihydro-1H-pyrazole hydrochloride. NMR data was consistent with the structure.

Workup

  1. customwas bubbled excess anhydrous hydrogen chloride
  2. filtrationThe precipitated solid was filtered
  3. washwashed with ether
  4. customdried

Sources & evidence

ORD record
ord-9b15f0bfe4524a51941384e299d50c5b
Source dataset
uspto-grants-1989_09
Patent number
US04863947

Reaction notes

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