Citric Acid → HCID 14579764, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-acetyl-4-hydroxy-3-methylbenzofuran (2 g; 10.5mmoles), potassium hydroxide pellets (4 g; 73mmoles), ethylene glycol (50 ml) and 99% hydrazine (3 ml) was heated at 100° C. for 2 hours and at 180° C. for 2 hours. The mixture was acidified with excess 20% citric acid solution and extracted with ether. The ether layer was dried (Na2SO4), filtered, concentrated, and chromatographed to obtain 1.2 g of the title compound as an oil which crystallized from hexane.

Provenance & Evidence