Citric Acid → HCID 14579765, compound

Participants

Reaction Steps

A mixture of 2-benzoyl-4-hydroxy-3-methyl-5-propylbenzofuran (1.2 g; 4mmoles), potassium hydroxide pellets (1.5 g; 28mmoles), ethylene glycol (25 ml) and 99% hydrazine (0.7 ml) was heated at 135°-155° C. for 3 hours. The mixture was cooled, acidified with 20% citric acid solution, extracted with ether, dried (Na2SO4), filtered, concentrated, and chromatographed to obtain 650 mg of the title compound as an oil which was crystallized from hexane.

Provenance & Evidence