反应详情

To a solution of 2-(p-methoxybenzyl)-3-methyl-4-hydroxy-5-propyl-7-dimethylaminomethylbenzofuran (0.2 gm; 0.54mmole) in ethanol (5 mL) was added sodium borohydride (0.2 gm, 5.45mmoles) and the reaction mixture was refluxed for 10 minutes. The reaction mixture was cooled, poured in a saturated solution of ammonium chloride, and extracted with ether. The organic phase was washed with with brine, dried (Na2SO4), and concentrated in vacuo. The residue was chromatographed on silica gel using 20% ethylacetate in hexane as eluent to yield 160 mg (91%) of 2-(p-methoxybenzyl)-3,7-dimethyl-4-hydroxy-5-propylbenzofuran, mp. 102°-104° C.

1. temperaturethe reaction mixture was refluxed for 10 minutes
2. temperatureThe reaction mixture was cooled
3. extractionextracted with ether
4. washThe organic phase was washed with with brine
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated in vacuo
7. customThe residue was chromatographed on silica gel using 20% ethylacetate in hexane as eluent