反应详情

温度

195 °C

A mixture of 2-(p-methoxybenzoyl)-3-methyl-4-hydroxybenzofuran (2.0 gm; 7.0 mmoles), 99% hydrazine (50 mL) and potassium hydroxide (2.7 gm; 49 mmoles) in ethylene glycol (50 mL) was heated at 140° C. for a period of 2.5 hours and at 195° C. for one hour. The reaction mixture was cooled, poured in water, and extracted with ethylacetate. The organic phase was washed with 20% citric acid, with brine, dried (Na2SO4), and concentrated in vacuo. The residue was chromatographed on silica gel using 20% ethylacetate in hexane as eluent to yield 700 gm (37%) of 2-(p-methoxybenzyl)-3-methyl-4-hydroxybenzofuran, mp.130°-133° C.

1. temperatureThe reaction mixture was cooled
2. extractionextracted with ethylacetate
3. washThe organic phase was washed with 20% citric acid, with brine
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated in vacuo
6. customThe residue was chromatographed on silica gel using 20% ethylacetate in hexane as eluent