Acetyl chloride → HCID 14579750, compound

Participants

Reaction Steps

Acetyl chloride (1.9 g, 25 mmol) was added dropwise to an ice-cold stirring mixture of O-(2-acetyl-3-hydroxy-4-propyl-6-chlorophenyl) dimethylthiocarbamate (6.3 g, 20 mmol) (Step a) and triethylamine (3.0 g, 30 mmol) in tetrahydrofuran (50 mL) The mixture was stirred for 2 hours and then diluted with water and diethyl ether. The organic layer was separated, dried (MgSO4), filtered and concentrated to obtain the title compound as an oil which crystallized on standing. The crystals were slurried with hexane, filtered and dried to give the title compound, m.p. 86°-88° C.

Provenance & Evidence