HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Difluoro-6-nitrophenol → 6-Amino-2,3-difluorophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Difluoro-6-nitrophenol | HCID 2733745 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-Amino-2,3-difluorophenol | HCID 2778441 | 99.9% |
Reaction Steps
A solution of 2,3-difluoro-6-nitrophenol (500 mg) in methanol (7 ml) was hydrogenated over 5% Pd/C (60 mg) for 6 hours. The reaction mixture was filtered under nitrogen stream and the filtrate was evaporated under reduced pressure to give 414 mg of crude 2-amino-5,6-difluorophenol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04864023 |
| Source dataset | uspto-grants-1989_09 |
| ORD ID | ord-456933d1dc874493b7f82558298d8652 |
| Source note | uspto-grants-1989_09 |