Hydrochloric Acid → Imidazo[1,2-a]pyridin-8-ol--hydrogen chloride (1/1)

Participants

Reaction Steps

In 80 ml of concentrated hydrochloric acid is dissolved 5 g of 8-benzyloxyimidazo[1,2-a]pyridine, and the solution is stirred at room temperature for 24 hours and then concentrated. After addition of 1-butanol, water is azeotropically removed by distillation, and the residue is crystallized from diethyl ether to give 3.8 g of the above-identified compound.

Provenance & Evidence