Hydrate;hydrochloride → HCID 178419078, compound

HRID 1607315Notes

Reaction equation

HRID 1607315 reaction equation
Cl.O.[NH2:3][CH:4]([C:11]([OH:13])=[O:12])[CH2:5][C:6]1[N:10]=[CH:9][NH:8][CH:7]=1.Cl.O>O>[NH2:3][C@H:4]([C:11]([OH:13])=[O:12])[CH2:5][C:6]1[N:10]=[CH:9][NH:8][CH:7]=1

Participants

4

Reactant 2

HCID 21885828Hydrate;hydrochlorideHCID 178479203HCID 178479203, compound

Product 1

HCID 178419078HCID 178419078, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

HCl.H2O: D,L-His.HCl.H2O (3.2 g) and the appropriate polymer were slurried in water (5 ml) and the slurry was heated to complete dissolution. The hot solution was filtered and allowed to stand at 50° C. for 20 hrs without agitation. The crystals were collected by filtration and the enantiomeric excess was determined. The results are summarized in Table VI.

Workup

  1. temperaturethe slurry was heated
  2. dissolutiondissolution
  3. filtrationThe hot solution was filtered
  4. filtrationThe crystals were collected by filtration

Sources & evidence

ORD record
ord-65c5551bfb56438f89c3c7abed1f1c95
Source dataset
uspto-grants-1989_09
Patent number
US04864031

Reaction notes

Loading…