反应详情

A 0.21 g quantity of nicotinoyl chloride (hydrochloride) was added to a solution of 0.20 g of 3'-O-benzyl-2'-deoxy-5-fluorouridine in 10 ml of pyridine, and the mixture was left to stand at 80° C. for 3 hours. The solvent was distilled off and the residue was dissolved in 30 ml of ethyl acetate. The solution was washed twice with 20 ml of water. The ethyl acetate layer was dried on anhydrous sodium sulfate and concentrated. The concentrate was placed on a silica gel column and eluted with chloroform, giving 0.18 g of the title compound in a yield of 69%.

1. waitthe mixture was left
2. distillationThe solvent was distilled off
3. dissolutionthe residue was dissolved in 30 ml of ethyl acetate
4. washThe solution was washed twice with 20 ml of water
5. dry with materialThe ethyl acetate layer was dried on anhydrous sodium sulfate
6. concentrationconcentrated
7. washeluted with chloroform