Acetic Anhydride → Methyl 2,2-dimethyl-3-(1-acetoxy-2,2-dichloro-3,3,3-trifluoropropyl)cyclopropanecarboxylate

HRID 1607360Notes

Reaction equation

HRID 1607360 reaction equation
[CH3:1][C:2]1([CH3:18])[CH:4]([CH:5]([OH:13])[C:6]([Cl:12])([Cl:11])[C:7]([F:10])([F:9])[F:8])[CH:3]1[C:14]([O:16][CH3:17])=[O:15].[C:19](OC(=O)C)(=[O:21])[CH3:20]>N1C=CC=CC=1>[CH3:1][C:2]1([CH3:18])[CH:4]([CH:5]([O:13][C:19](=[O:21])[CH3:20])[C:6]([Cl:11])([Cl:12])[C:7]([F:8])([F:9])[F:10])[CH:3]1[C:14]([O:16][CH3:17])=[O:15]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 13602242Methyl 2,2-dimethyl-3-(1-hydroxy-2,2-dichloro-3,3,3-trifluoropropyl)cyclopropanecarboxylate

Product 1

HCID 13956728Methyl 2,2-dimethyl-3-(1-acetoxy-2,2-dichloro-3,3,3-trifluoropropyl)cyclopropanecarboxylateYield 93%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To 50 mg (0.16 mmol) of methyl 2,2-dimethyl-3-(1-hydroxy-2,2-dichloro-3,3,3-trifluoropropyl)cyclopropanecarboxylate obtained in Example 1, 0.2 ml of acetic anhydride and 0.2 ml of pyridine were added, and the mixture was left overnight at room temperature. In the same manner as in Example 9, 53 mg of methyl 2,2-dimethyl-3-(1-acetoxy-2,2-dichloro-3,3,3-trifluoropropyl)cyclopropanecarboxylate was obtained as a colorless oily substance. Yield: 93%. The physical property values were the same as those in Example 7.

Sources & evidence

ORD record
ord-e6780cc4fadd4681911ca4ad81106cbd
Source dataset
uspto-grants-1989_09
Patent number
US04864052

Reaction notes

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